Measurements of Selected Brominated Flame Retardants in Nursing Women: Implications for Human Exposure
Identifieur interne : 000290 ( Canada/Analysis ); précédent : 000289; suivant : 000291Measurements of Selected Brominated Flame Retardants in Nursing Women: Implications for Human Exposure
Auteurs : Simon Ningsun Zhou [Canada] ; Angelina Buchar [Canada] ; Shabana Siddique [Canada] ; Larissa Takser [Canada] ; Nadia Abdelouahab [Canada] ; JIPING ZHU [Canada]Source :
- Environmental science & technology [ 0013-936X ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Canada.
- topic : Santé publique, Lait maternel.
English descriptors
- KwdEn :
Abstract
We have examined several emerging brominated flame retardants (BFRs) including 2-ethyl-1-hexyl-2,3,4,5-tetrabromobenzoate (TBB), bis(2-ethylhexyl) tetrabromophthalate (TBPH), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), 4,5,6,7-tetrabromo-1,1,3-trimethyl-3-(2,3,4,5-tetrabromophenyl)-indane (OBIND), and decabromodiphenyl ethane (DBDPE) in paired human maternal serum (n = 102) and breast milk (n = 105) collected in 2008-2009 in the Sherbrooke region in Canada. Three legacy BFRs were also included in the study for comparison: decabromobiphenyl (BB-209), 2,2',4,4',5,5'-hexabromobiphenyl (BB-153), and 2,2',4,4',5,5'-hexabromodiphenyl ethers (BDE-153). TBB, BB-153, and BDE-153 had detection frequencies greater than 55% in both serum and milk samples. Their lipid weight (lw) adjusted median concentrations (ng g-1 lw) in serum and milk were 1.6 and 0.41 for TBB, 0.48 and 0.31 for BB-153, and 1.5 and 4.4 for BDE-153, respectively. The detection frequencies for the other BFRs measured in serum and milk were 16.7% and 32.4% for TBPH, 3.9% and 0.0% for BTBPE, 2.0% and 0.0% for BB-209, 9.8% and 1.0% for OBIND, and 5.9% and 8.6% for DBDPE. The ratio of TBB over the sum of TBB and TBPH (f.TBB) in serum (0.23) was lower than that in milk (0.46), indicating TBB has a larger tendency than TBPH to be redistributed from blood to milk. Overall, these data confirm the presence of non-PBDE BFRs in humans, and the need to better understand their sources, routes of exposure, and potential human health effects.
Affiliations:
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Simon" sort="Ningsun Zhou, Simon" uniqKey="Ningsun Zhou S" first="Simon" last="Ningsun Zhou">Simon Ningsun Zhou</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Exposure and Biomonitoring Division, Health Canada</s1><s2>Ottawa, Ontario K1A 0K9</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Ottawa, Ontario K1A 0K9</wicri:noRegion></affiliation></author><author><name sortKey="Buchar, Angelina" sort="Buchar, Angelina" uniqKey="Buchar A" first="Angelina" last="Buchar">Angelina Buchar</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Existing Substances Risk Assessment Bureau, Health Canada</s1><s2>Ottawa, Ontario K1A 0K9</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Ottawa, Ontario K1A 0K9</wicri:noRegion></affiliation></author><author><name sortKey="Siddique, Shabana" sort="Siddique, Shabana" uniqKey="Siddique S" first="Shabana" last="Siddique">Shabana Siddique</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Exposure and Biomonitoring Division, Health Canada</s1><s2>Ottawa, Ontario K1A 0K9</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Ottawa, Ontario K1A 0K9</wicri:noRegion></affiliation></author><author><name sortKey="Takser, Larissa" sort="Takser, Larissa" uniqKey="Takser L" first="Larissa" last="Takser">Larissa Takser</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Département de Pédiatrie, Faculté de Médecine, Université de Sherbrooke</s1><s2>Sherbrooke, Québec J1K 2R1</s2><s3>CAN</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Sherbrooke, Québec J1K 2R1</wicri:noRegion></affiliation></author><author><name sortKey="Abdelouahab, Nadia" sort="Abdelouahab, Nadia" uniqKey="Abdelouahab N" first="Nadia" last="Abdelouahab">Nadia Abdelouahab</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Département de Pédiatrie, Faculté de Médecine, Université de Sherbrooke</s1><s2>Sherbrooke, Québec J1K 2R1</s2><s3>CAN</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Sherbrooke, Québec J1K 2R1</wicri:noRegion></affiliation></author><author><name sortKey="Jiping Zhu" sort="Jiping Zhu" uniqKey="Jiping Zhu" last="Jiping Zhu">JIPING ZHU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Exposure and Biomonitoring Division, Health Canada</s1><s2>Ottawa, Ontario K1A 0K9</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Ottawa, Ontario K1A 0K9</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Environmental science & technology</title><title level="j" type="abbreviated">Environ. sci. technol.</title><idno type="ISSN">0013-936X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Environmental science & technology</title><title level="j" type="abbreviated">Environ. sci. technol.</title><idno type="ISSN">0013-936X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological fluid</term><term>Breast milk</term><term>Bromine Organic compounds</term><term>Canada</term><term>Concentration measurement</term><term>Emerging pollutant</term><term>Flame retardant</term><term>Health and environment</term><term>Milk transfer</term><term>Mother</term><term>Organic bromine compounds</term><term>Public health</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Retardateur flamme</term><term>Brome composé organique</term><term>Brome Composé organique</term><term>Passage lait</term><term>Santé publique</term><term>Santé et environnement</term><term>Mesure concentration</term><term>Liquide biologique</term><term>Mère</term><term>Lait maternel</term><term>Canada</term><term>Polluant émergent</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Canada</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Santé publique</term><term>Lait maternel</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have examined several emerging brominated flame retardants (BFRs) including 2-ethyl-1-hexyl-2,3,4,5-tetrabromobenzoate (TBB), bis(2-ethylhexyl) tetrabromophthalate (TBPH), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), 4,5,6,7-tetrabromo-1,1,3-trimethyl-3-(2,3,4,5-tetrabromophenyl)-indane (OBIND), and decabromodiphenyl ethane (DBDPE) in paired human maternal serum (n = 102) and breast milk (n = 105) collected in 2008-2009 in the Sherbrooke region in Canada. Three legacy BFRs were also included in the study for comparison: decabromobiphenyl (BB-209), 2,2',4,4',5,5'-hexabromobiphenyl (BB-153), and 2,2',4,4',5,5'-hexabromodiphenyl ethers (BDE-153). TBB, BB-153, and BDE-153 had detection frequencies greater than 55% in both serum and milk samples. Their lipid weight (lw) adjusted median concentrations (ng g<sup>-1 </sup>lw) in serum and milk were 1.6 and 0.41 for TBB, 0.48 and 0.31 for BB-153, and 1.5 and 4.4 for BDE-153, respectively. The detection frequencies for the other BFRs measured in serum and milk were 16.7% and 32.4% for TBPH, 3.9% and 0.0% for BTBPE, 2.0% and 0.0% for BB-209, 9.8% and 1.0% for OBIND, and 5.9% and 8.6% for DBDPE. The ratio of TBB over the sum of TBB and TBPH (f.<sub>TBB</sub>) in serum (0.23) was lower than that in milk (0.46), indicating TBB has a larger tendency than TBPH to be redistributed from blood to milk. Overall, these data confirm the presence of non-PBDE BFRs in humans, and the need to better understand their sources, routes of exposure, and potential human health effects.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Ningsun Zhou, Simon" sort="Ningsun Zhou, Simon" uniqKey="Ningsun Zhou S" first="Simon" last="Ningsun Zhou">Simon Ningsun Zhou</name></noRegion><name sortKey="Abdelouahab, Nadia" sort="Abdelouahab, Nadia" uniqKey="Abdelouahab N" first="Nadia" last="Abdelouahab">Nadia Abdelouahab</name><name sortKey="Buchar, Angelina" sort="Buchar, Angelina" uniqKey="Buchar A" first="Angelina" last="Buchar">Angelina Buchar</name><name sortKey="Jiping Zhu" sort="Jiping Zhu" uniqKey="Jiping Zhu" last="Jiping Zhu">JIPING ZHU</name><name sortKey="Siddique, Shabana" sort="Siddique, Shabana" uniqKey="Siddique S" first="Shabana" last="Siddique">Shabana Siddique</name><name sortKey="Takser, Larissa" sort="Takser, Larissa" uniqKey="Takser L" first="Larissa" last="Takser">Larissa Takser</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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